In patients with severe, refractory hyperemesis gravidarum, two off label medications were associated with rapid and clinically meaningful reductions in nausea, vomiting, and weight loss.

Download the Abstract

Objective:

To evaluate the effectiveness of two off-label medications for managing hyperemesis gravidarum (HG) unresponsive to standard therapies.

Authors:
Andrew Housholder, MD, The HG and Morning Sickness Clinic
Marlena Fezjo, Ph.D, USC, Keck School of Medicine, HER Foundation
Ellie Lewis, John Hopkins University
Isabella Clements, UAB

Thank you to Kimber MacGibbon, MS, BSN, RN and Aimée Brecht-Doscher, MD, both from the HER Foundation, for reviewing this abstract prior to publication.

Presented at SMFM in February 2026

Download the Abstract
Download the Poster

Dr. Housholder works in tandem with OBGYNs throughout the United States to treat patients with severe hyperemesis gravidarum. If you’d like your patient to have a consult, they’ll need a second opinion consult form faxed to our clinic at 205-549-8711. Dr. Housholder will evaluate the patient and fax you treatment recommendations. Our patients report satisfaction of less than 4/10 for HG care with prior pregnancies, and greater than 9/10 with our care. They also have 15% higher satisfaction with their OBs when they are referred to us for HG care.

Referral Fax Line: 205-549-8711